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penP [2019-01-16 12:01:15]
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penP [2019-01-16 12:01:15]

beta-lactamase
locus
BSU18800
pI
9.21
mw
33.29 kDa
protein length
306 aa Sequence Blast
gene length
918 bp Sequence Blast
function
resistance to beta-lactam antibiotics
product
beta-lactamase
essential
no
ec
3.5.2.6
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins]

    • Gene

    Coordinates
    2,048,533 → 2,049,453

    The protein

    Catalyzed reaction/ biological activity

  • A beta-lactam + H2O = a substituted beta-amino acid (according to Swiss-Prot)

    • Structure

  • [PDB|3KGM] (from ''B. licheniformis'', 58% identity, 79% similarity)

    • [SW|Localization]

  • extracellular (signal peptide) [Pubmed|18957862]

    • Expression and Regulation

    Operons

    genes
    [gene|713BAB7190E1F86C55103049B29072F00E0DFFB3|penP]
    description
    [Pubmed|22383849]
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    Biological materials

    Mutant

  • BKE18800 (Δ[gene|713BAB7190E1F86C55103049B29072F00E0DFFB3|penP]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE18800 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAGGCCTCCTCATTCAA, downstream forward: _UP4_TAATATGTTTAGCCTTTTGC
  • BKK18800 (Δ[gene|713BAB7190E1F86C55103049B29072F00E0DFFB3|penP]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK18800 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCAGGCCTCCTCATTCAA, downstream forward: _UP4_TAATATGTTTAGCCTTTTGC

    • References

  • 18957862